- Fentanyl transdermal patches are contraindicated in opioid-naive patients in the UK
- New measures to reduce the risk of potentially fatal overdose associated with once-weekly methotrexate
- Risk of cutaneous amyloidosis at insulin injection sites and impact on glycaemic control.
MHRA Drug Safety Update recommends opioid conversations
New fentanyl contraindications
The September MHRA Drug Safety Update recommends that prescribers and patients agree a treatment strategy for the use of opioids for non-cancer pain, to reduce the risks of addiction and dependence associated with long term use. Other advice contained in the update: